The Final Report, that describes the achievements of ORCHID and refers to the relevant documents that have been delivered during the 2-year ORCHID project, can be downloaded here.
References
- Barrile et al., Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems; Clin Pharmacol Ther. 2018 Dec;104(6):1240-1248. doi: 1002/cpt.1054.
- Song et al., A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines; Sci Rep. 2018, 8(1):17949. doi: 1038/s41598-018-36381-5.
- Vormann et al., Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules; AAPS J. 2018 Aug 14;20(5):90. doi: 1208/s12248-018-0248-z.
- Wevers et al., High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform; Sci Rep. 2016 Dec 9;6:38856. doi: 10.1038/srep38856.
- Zhang et al.; A 3D human lung-on-a-chip model for nanotoxicity testing; Toxicol Res (Camb). 2018;7(6):1048-1060. doi: 1039/c8tx00156a.
- Osaki et al., Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons; Sci. Adv. 2018; 4 : eaat5847 10 October 2018. doi: 1126/sciadv.aat5847,
- Mastrangeli et al.; “Organ-on-chip in development: Towards a roadmap for organs-on-chip”; ALTEX – Alternatives to animal experimentation, 36(4), pp. 650-668, 2019, doi: 14573/altex.1908271.
- Mastrangeli et al.; “Building blocks for a European Organ-on-Chip roadmap”, ALTEX – Alternatives to animal experimentation, 36(3), pp. 481-492, 2019. doi: 14573/altex.1905221.
- “State of the art of regulation, standardization and ethics” (D5.1)
- “Organ-on-Chip – outlook on the regulatory pathway” (D5.4)
- “Organ-on-Chip as next drug discovery route” (D5.8)
- “Societal primer on ethical use and implications” (D5.2)
- “Guideline for the research community” (D5.3)
- “Policy paper on ethics, regulatory and standardization” (D5.6)
- “Primer on organ-on-Chip – Desirable, safe & efficient” (D5.7)
- Franzen et al,; Impact of organ-on-a-chip technology on pharmaceutical R&D costs, Drug Discovery Today; Volume 24, Issue 9, September 2019, Pages 1720-1724. doi: 1016/j.drudis.2019.06.003.
- “Current and future potential business models” (D3.2)
- https://www.forbes.com/sites/mariannacerini/2016/03/23/chinas-economy-is-slowing-but-their-pet-economy-is-booming/#20d86d594ef7
- “Questionnaire for stakeholders” (D3.3)
- “Identification of training needs” (D3.4)
- Brochure “Organ-on-Chip In Development: Towards a European roadmap for Organ-on-Chip”
- Brochure “Organ-on-Chip In Development: Building blocks for a European Organ-on-Chip roadmap”
- “Final report on dissemination and communication” (D6.3)
- Program, participants + slide presentations final meeting