The Final Report, that describes the achievements of ORCHID and refers to the relevant documents that have been delivered during the 2-year ORCHID project, can be downloaded here.



  1. Barrile et al., Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems; Clin Pharmacol Ther. 2018 Dec;104(6):1240-1248. doi: 1002/cpt.1054.
  2. Song et al., A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines; Sci Rep. 2018, 8(1):17949. doi: 1038/s41598-018-36381-5.
  3. Vormann et al., Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules; AAPS J. 2018 Aug 14;20(5):90. doi: 1208/s12248-018-0248-z.
  4. Wevers et al., High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform; Sci Rep. 2016 Dec 9;6:38856. doi: 10.1038/srep38856.
  5. Zhang et al.; A 3D human lung-on-a-chip model for nanotoxicity testing; Toxicol Res (Camb). 2018;7(6):1048-1060. doi: 1039/c8tx00156a.
  6. Osaki et al., Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons; Sci. Adv. 2018; 4 : eaat5847 10 October 2018. doi: 1126/sciadv.aat5847,
  7. Mastrangeli et al.; “Organ-on-chip in development: Towards a roadmap for organs-on-chip”; ALTEX – Alternatives to animal experimentation, 36(4), pp. 650-668, 2019, doi: 14573/altex.1908271.
  8. Mastrangeli et al.; “Building blocks for a European Organ-on-Chip roadmap”, ALTEX – Alternatives to animal experimentation, 36(3), pp. 481-492, 2019. doi: 14573/altex.1905221.
  9. “State of the art of regulation, standardization and ethics” (D5.1)
  10. “Organ-on-Chip – outlook on the regulatory pathway” (D5.4)
  11. “Organ-on-Chip as next drug discovery route” (D5.8)
  12. “Societal primer on ethical use and implications” (D5.2)
  13. “Guideline for the research community” (D5.3)
  14. “Policy paper on ethics, regulatory and standardization” (D5.6)
  15. “Primer on organ-on-Chip – Desirable, safe & efficient” (D5.7)
  16. Franzen et al,; Impact of organ-on-a-chip technology on pharmaceutical R&D costs, Drug Discovery Today; Volume 24, Issue 9, September 2019, Pages 1720-1724. doi: 1016/j.drudis.2019.06.003.
  17. “Current and future potential business models” (D3.2)
  19. “Questionnaire for stakeholders” (D3.3)
  20. “Identification of training needs” (D3.4)
  21. Brochure “Organ-on-Chip In Development: Towards a European roadmap for Organ-on-Chip
  22. Brochure “Organ-on-Chip In Development: Building blocks for a European Organ-on-Chip roadmap
  23. “Final report on dissemination and communication” (D6.3)
  24. Program, participants + slide presentations final meeting


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